Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain

نویسندگان

  • Ling-Xing Shan
  • Ping-Hua Sun
  • Bao-Qin Guo
  • Xing-Jun Xu
  • Zhi-Qiang Li
  • Jia-Zhi Sun
  • Shu-Feng Zhou
  • Wei-Min Chen
چکیده

Seventeen acylides bearing an aryl-tetrazolyl alkyl-substituted side chain were synthesized, starting from clarithromycin, via several reactions including hydrolysis, acetylating, esterification, carbamylation, and Michael addition. The structures of all new compounds were confirmed by (1)H nuclear magnetic resonance spectroscopy, (13)C nuclear magnetic resonance spectroscopy, and mass spectrometry. All these synthesized acylides were evaluated for in vitro antimicrobial activities against gram-positive pathogens (Staphylococcus aureus, Staphylococcus epidermidis) and gram-negative pathogens (Pseudomonas aeruginosa, Escherichia coli), using the broth microdilution method. Results showed that compounds 10 e, 10 f, 10 g, 10 h, 10 o have good antibacterial activities.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2014